Researchers investigate connection between loss of motivation and Alzheimer’s disease progression

Journal Reference: Changyong Guo, Di Wen, Yihong Zhang, Richie Mustaklem, Basil Mustaklem, Miou Zhou, Tao Ma, Yao-Ying Ma. Amyloid-β oligomers in the nucleus accumbens decrease motivation via insertion of calcium-permeable AMPA receptors. Molecular Psychiatry, 2022; DOI: 10.1038/s41380-022-01459-0 The study, led by Yao-Ying Ma, MD, PhD, assistant professor of pharmacology and toxicology, was recently featured in … Read more

When it comes to preventing Alzheimer’s, women respond better than men

Journal Reference: N. Saif, H. Hristov, K. Akiyoshi, K. Niotis, I.E. Ariza, N. Malviya, P. Lee, J. Melendez, G. Sadek, K. Hackett, A. Rahman, J. Meléndez-Cabrero, C.E. Greer, L. Mosconi, R. Krikorian, R.S. Isaacson. Sex-Driven Differences in the Effectiveness of Individualized Clinical Management of Alzheimer’s Disease Risk. The Journal Of Prevention of Alzheimer’s Disease, 2022; … Read more

Genetic changes differed, increased in people with Alzheimer’s disease

Journal Reference: Miller, M.B., Huang, A.Y., Kim, J. et al. Somatic genomic changes in single Alzheimer’s disease neurons. Nature, 2022 DOI: 10.1038/s41586-022-04640-1 “As we age, neurons are known to accumulate somatic mutations. In AD neurons, however, we see more mutations and DNA alterations,” said lead author Michael B. Miller, MD, PhD, of the Department of … Read more

In the race to solve Alzheimer’s illness, scientists find more needles in the haystack

Journal Reference: Céline Bellenguez et al. New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nature Genetics, 2022; 54 (4): 412 DOI: 10.1038/s41588-022-01024-z It’s a huge haystack, and Alzheimer’s-related genetic variations, like needles, are miniscule in comparison. Sudha Seshadri, MD, and other faculty at The University of Texas Health Science Center at … Read more

Psychiatric symptoms in Alzheimer´s disease

Journal Reference: Maurits Johansson, Erik Stomrud, Per Mårten Johansson, Anna Svenningsson, Sebastian Palmqvist, Shorena Janelidze, Danielle van Westen, Niklas Mattsson-Carlgren, Oskar Hansson. Development of Apathy, Anxiety, and Depression in Cognitively Unimpaired Older Adults: Effects of Alzheimer’s Disease Pathology and Cognitive Decline. Biological Psychiatry, 2022; DOI: 10.1016/j.biopsych.2022.01.012 Cognitive symptoms combined with elevated levels of certain proteins … Read more

Key signaling pathway in immune cells could be new Alzheimer’s target

Journal Reference: Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue-Ann Mok, Jason E. Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan. Microglial NF-κB drives tau spreading and toxicity in a … Read more

Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease progression

Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease progression – NovLink Home Mash I Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease progression We would like to say thanks to the writer of this short article for this amazing web content Study identifies … Read more

Study reports potential target and compounds to slow the development of Alzheimer’s disease

Journal Reference: Khanh V. Do, Erik Hjorth, Ying Wang, Bokkyoo Jun, Marie-Audrey I. Kautzmann, Makiko Ohshima, Maria Eriksdotter, Marianne Schultzberg, Nicolas G. Bazan. Cerebrospinal Fluid Profile of Lipid Mediators in Alzheimer’s Disease. Cellular and Molecular Neurobiology, 2022; DOI: 10.1007/s10571-022-01216-5 Specialized lipid mediators are bioactive compounds composed of polyunsaturated fatty acids like DHA and EPA. They … Read more

Genetic ‘hotspots’ that speed up and slow down brain aging could provide new targets for Alzheimer’s drugs

Genetic ‘hotspots’ that speed up and slow down brain aging could provide new targets for Alzheimer’s drugs – NovLink Home Mash E Genetic ‘hotspots’ that speed up and slow down brain aging could provide new targets for Alzheimer’s drugs We want to say thanks to the writer of this short article for this incredible material … Read more

Loss of neurons, not lack of sleep, makes Alzheimer’s patients drowsy

Journal Reference: Jun Y. Oh, Christine M. Walsh, Kamalini Ranasinghe, Mihovil Mladinov, Felipe L. Pereira, Cathrine Petersen, Neus Falgàs, Leslie Yack, Tia Lamore, Rakin Nasar, Caroline Lew, Song Li, Thomas Metzler, Quentin Coppola, Natalie Pandher, Michael Le, Hilary W. Heuer, Helmut Heinsen, Salvatore Spina, William W. Seeley, Joel Kramer, Gil D. Rabinovici, Adam L. Boxer, … Read more

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