Gastrointestinal issues linked with anxiousness, social withdrawal for kids with autism

Journal Reference: Kristen Dovgan, Kyra Gynegrowski, Bradley J. Ferguson. Bidirectional relationship between internalizing symptoms and gastrointestinal problems in youth with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 2022; DOI: 10.1007/s10803-022-05539-6 A new study at the University of Missouri found a “bi-directional” relationship between gastrointestinal issues and internalized symptoms in children and adolescents with … Read more

Some autism spectrum disorder symptoms linked to astrocytes

Journal Reference: Megan Allen, Ben S. Huang, Michael J. Notaras, Aiman Lodhi, Estibaliz Barrio-Alonso, Pablo J. Lituma, Paul Wolujewicz, Jonathan Witztum, Francesco Longo, Maoshan Chen, David W. Greening, Eric Klann, M. Elizabeth Ross, Conor Liston, Dilek Colak. Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling. Molecular Psychiatry, 2022; … Read more

Scientists identify overgrowth of key brain structure in babies who later develop autism

Journal Reference: Mark D. Shen, Meghan R. Swanson, Jason J. Wolff, Jed T. Elison, Jessica B. Girault, Sun Hyung Kim, Rachel G. Smith, Michael M. Graves, Leigh Anne H. Weisenfeld, Lisa Flake, Leigh MacIntyre, Julia L. Gross, Catherine A. Burrows, Vladimir S. Fonov, D. Louis Collins, Alan C. Evans, Guido Gerig, Robert C. McKinstry, Juhi … Read more

Scientist links epigenetic biomarkers to gastrointestinal issues for kids with autism

Journal Reference: David Q. Beversdorf, Kristin Sohl, David Levitskiy, Priscilla Tennant, Robin P. Goin-Kochel, Rebecca C. Shaffer, Alexandra Confair, Frank A. Middleton, Steven D. Hicks. Saliva RNA Biomarkers of Gastrointestinal Dysfunction in Children With Autism and Neurodevelopmental Disorders: Potential Implications for Precision Medicine. Frontiers in Psychiatry, 2022; 12 DOI: 10.3389/fpsyt.2021.824933 In a recent study, Beversdorf … Read more

Study shows differences between brains of ladies, boys with autism

Journal Reference: Kaustubh Supekar, Carlo de los Angeles, Srikanth Ryali, Kaidi Cao, Tengyu Ma, Vinod Menon. Deep learning identifies robust gender differences in functional brain organization and their dissociable links to clinical symptoms in autism. The British Journal of Psychiatry, 2022; 1 DOI: 10.1192/bjp.2022.13 The differences, identified by analyzing hundreds of brain scans with artificial … Read more

Insight into the genetics of autism offers hope for new drug treatments

Journal Reference: Rebecca B. Hughes, Jayde Whittingham‐Dowd, Steven J. Clapcote, Susan J. Broughton, Neil Dawson. Altered medial prefrontal cortex and dorsal raphé activity predict genotype and correlate with abnormal learning behavior in a mouse model of autism‐associated 2p16.3 deletion. Autism Research, 2022; DOI: 10.1002/aur.2685 In the human genome small sections of DNA have been found … Read more

Scientists discover biological mechanisms caused by deficits in high-risk autism gene

Journal Reference: Simone Afriyie, Blake A Creighton, Deepa Ajit, Cristine R Casingal, Kayleigh M Voos, Joan Reger, April M Burch, Eric Dyne, Julia Bay, Jeffrey K Huang, ES Anton, Meng-Meng Fu, Damaris N Lorenzo. Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A. eLife, 2021; 10 DOI: 10.7554/eLife.69815 The discovery, … Read more