Structure of a bacterial ‘drug pump’ reveals new way to counter hospital-borne infection

Journal Reference: Douglas N. Brawley, David B. Sauer, Jianping Li, Xuhui Zheng, Akiko Koide, Ganesh S. Jedhe, Tiffany Suwatthee, Jinmei Song, Zheng Liu, Paramjit S. Arora, Shohei Koide, Victor J. Torres, Da-Neng Wang, Nathaniel J. Traaseth. Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus. Nature Chemical Biology, 2022; DOI: 10.1038/s41589-022-00994-9 … Read more

Bacterial enzyme makes new type of biodegradable polymer

Journal Reference: Spencer S. Macdonald, Jose H. Pereira, Feng Liu, Gregor Tegl, Andy DeGiovanni, Jacob F. Wardman, Samuel Deutsch, Yasuo Yoshikuni, Paul D. Adams, Stephen G. Withers. A Synthetic Gene Library Yields a Previously Unknown Glycoside Phosphorylase That Degrades and Assembles Poly-β-1,3-GlcNAc, Completing the Suite of β-Linked GlcNAc Polysaccharides. ACS Central Science, 2022; DOI: 10.1021/acscentsci.1c01570 … Read more

Engineered bacterial strains could fertilize crops, reduce waterways pollution

Journal Reference: Florence Mus, Devanshi Khokhani, April M. MacIntyre, Esther Rugoli, Ray Dixon, Jean-Michel Ané, John W. Peters. Genetic determinants of ammonium excretion in nifL mutants of Azotobacter vinelandii. Applied and Environmental Microbiology, 2022; DOI: 10.1128/AEM.01876-21 “We presented conclusive evidence that ammonia released is transferred to the rice plants,” said Florence Mus, Ph.D., assistant research … Read more

Ultrashort-pulse lasers kill bacterial superbugs, spores

Journal Reference: Shaw‐Wei D. Tsen, John Popovich, Megan Hodges, Shelley E. Haydel, Kong‐Thon Tsen, Gail Sudlow, Elizabeth A. Mueller, Petra Anne Levin, Samuel Achilefu. Inactivation of multidrug‐resistant bacteria and bacterial spores and generation of high‐potency bacterial vaccines using ultrashort pulsed lasers. Journal of Biophotonics, 2021; DOI: 10.1002/jbio.202100207 Researchers at Washington University School of Medicine in … Read more