Correcting night blindness in dogs

Journal Reference: Keiko Miyadera, Evelyn Santana, Karolina Roszak, Sommer Iffrig, Meike Visel, Simone Iwabe, Ryan F. Boyd, Joshua T. Bartoe, Yu Sato, Alexa Gray, Ana Ripolles-Garcia, Valérie L. Dufour, Leah C. Byrne, John G. Flannery, William A. Beltran, Gustavo D. Aguirre. Targeting ON-bipolar cells by AAV gene therapy stably reverses LRIT3 -congenital stationary night blindness. … Read more

Scientists pinpoint genetic target with promise for treating many forms of blindness

Journal Reference: Laura K. Finnegan, Naomi Chadderton, Paul F. Kenna, Arpad Palfi, Michael Carty, Andrew G. Bowie, Sophia Millington-Ward, G. Jane Farrar. SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration. International Journal of Molecular Sciences, 2022; 23 (3): 1606 DOI: 10.3390/ijms23031606 The scientists have … Read more

New gene therapy method improves vision in mice with congenital blindness

Journal Reference: Koji M. Nishiguchi, Kosuke Fujita, Fuyuki Miya, Shota Katayama, Toru Nakazawa. Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors restores vision in mice. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-019-14181-3 The results were published on January 24th in Nature Communications. This new method is an alternative strategy of gene supplementation, … Read more

Novel gene therapy platform speeds search for ways to cure blindness

Journal Reference: Bilge E Öztürk, Molly E Johnson, Michael Kleyman, Serhan Turunç, Jing He, Sara Jabalameli, Zhouhuan Xi, Meike Visel, Valérie L Dufour, Simone Iwabe, Felipe Pompeo Marinho, Gustavo D Aguirre, José-Alain Sahel, David V Schaffer, Andreas R Pfenning, John G Flannery, William A Beltran, William R Stauffer, Leah C Byrne. scAAVengr, a transcriptome-based pipeline … Read more