Researchers investigate connection between loss of motivation and Alzheimer’s disease progression

Journal Reference: Changyong Guo, Di Wen, Yihong Zhang, Richie Mustaklem, Basil Mustaklem, Miou Zhou, Tao Ma, Yao-Ying Ma. Amyloid-β oligomers in the nucleus accumbens decrease motivation via insertion of calcium-permeable AMPA receptors. Molecular Psychiatry, 2022; DOI: 10.1038/s41380-022-01459-0 The study, led by Yao-Ying Ma, MD, PhD, assistant professor of pharmacology and toxicology, was recently featured in … Read more

Lipidomics provides new biomarkers for cardiovascular disease and Type 2 diabetes

Journal Reference: Fabian Eichelmann, Laury Sellem, Clemens Wittenbecher, Susanne Jäger, Olga Kuxhaus, Marcela Prada, Rafael Cuadrat, Kim G. Jackson, Julie A. Lovegrove, Matthias B. Schulze. Deep Lipidomics in Human Plasma – Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation. Circulation, 2022; DOI: 10.1161/CIRCULATIONAHA.121.056805 Cardiovascular disease is the leading cause of death worldwide, accounting for … Read more

Genetic changes differed, increased in people with Alzheimer’s disease

Journal Reference: Miller, M.B., Huang, A.Y., Kim, J. et al. Somatic genomic changes in single Alzheimer’s disease neurons. Nature, 2022 DOI: 10.1038/s41586-022-04640-1 “As we age, neurons are known to accumulate somatic mutations. In AD neurons, however, we see more mutations and DNA alterations,” said lead author Michael B. Miller, MD, PhD, of the Department of … Read more

New miniature heart could help speed heart disease cures

Journal Reference: Christos Michas, M. Çağatay Karakan, Pranjal Nautiyal, Jonathan G. Seidman, Christine E. Seidman, Arvind Agarwal, Kamil Ekinci, Jeroen Eyckmans, Alice E. White, Christopher S. Chen. Engineering a living cardiac pump on a chip using high-precision fabrication. Science Advances, 2022; 8 (16) DOI: 10.1126/sciadv.abm3791 Now, an interdisciplinary team of engineers, biologists, and geneticists has … Read more

People with diabetes and cognitive decline may be at higher risk for heart disease

Journal Reference: Tali Cukierman-Yaffe, Hertzel C Gerstein, Jan Basile, M Angelyn Bethel, Ernesto G Cardona-Muñoz, Ignacio Conget, Gilles Dagenais, Edward Franek, Stephanie Hall, Nicolae Hancu, Petr Jansky, Mark Lakshmanan, Fernando Lanas, Lawrence A Leiter, Patricio Lopez-Jaramillo, Valdis Pirags, Nana Pogosova, Jeffrey Probstfield, Purnima Rao-Melacini, Chinthanie Ramasundarahettige, Peter J Raubenheimer, Matthew C Riddle, Lars Rydén, Jonathan … Read more

Mental illness associated with increased death from cardiovascular disease

Journal Reference: Amanda M Lambert, Helen M Parretti, Emma Pearce, Malcolm J Price, Mark Riley, Ronan Ryan, Natalie Tyldesley-Marshall, Tuba Saygın Avşar, Gemma Matthewman, Alexandra Lee, Khaled Ahmed, Maria Lisa Odland, Christoph U. Correll, Marco Solmi, Tom Marshall. Temporal trends in associations between severe mental illness and risk of cardiovascular disease: A systematic review and … Read more

Psychiatric symptoms in Alzheimer´s disease

Journal Reference: Maurits Johansson, Erik Stomrud, Per Mårten Johansson, Anna Svenningsson, Sebastian Palmqvist, Shorena Janelidze, Danielle van Westen, Niklas Mattsson-Carlgren, Oskar Hansson. Development of Apathy, Anxiety, and Depression in Cognitively Unimpaired Older Adults: Effects of Alzheimer’s Disease Pathology and Cognitive Decline. Biological Psychiatry, 2022; DOI: 10.1016/j.biopsych.2022.01.012 Cognitive symptoms combined with elevated levels of certain proteins … Read more

About 1 in 4 adults has an often-missed liver disorder linked to higher heart disease risk

Journal Reference: P. Barton Duell, Francine K. Welty, Michael Miller, Alan Chait, Gmerice Hammond, Zahid Ahmad, David E. Cohen, Jay D. Horton, Gregg S. Pressman, Peter P. Toth. Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association. Arteriosclerosis, Thrombosis, and Vascular Biology, 2022; DOI: 10.1161/ATV.0000000000000153 An American Heart Association … Read more

Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease progression

Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease progression – NovLink Home Mash I Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease progression We would like to say thanks to the writer of this short article for this amazing web content Study identifies … Read more

Study reports potential target and compounds to slow the development of Alzheimer’s disease

Journal Reference: Khanh V. Do, Erik Hjorth, Ying Wang, Bokkyoo Jun, Marie-Audrey I. Kautzmann, Makiko Ohshima, Maria Eriksdotter, Marianne Schultzberg, Nicolas G. Bazan. Cerebrospinal Fluid Profile of Lipid Mediators in Alzheimer’s Disease. Cellular and Molecular Neurobiology, 2022; DOI: 10.1007/s10571-022-01216-5 Specialized lipid mediators are bioactive compounds composed of polyunsaturated fatty acids like DHA and EPA. They … Read more