Wearables can track COVID signs, other diseases

Journal Reference: Caleb Mayer, Jonathan Tyler, Yu Fang, Christopher Flora, Elena Frank, Muneesh Tewari, Sung Won Choi, Srijan Sen, Daniel B. Forger. Consumer-grade wearables identify changes in multiple physiological systems during COVID-19 disease progression. Cell Reports Medicine, 2022; 3 (4): 100601 DOI: 10.1016/j.xcrm.2022.100601 That’s according to a University of Michigan study that examined the effects … Read more

New information about amyloid filaments in neurodegenerative diseases

Journal Reference: Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J. Garringer, Ruben Vidal, Grace I. Hallinan, Kathy L. Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G. Kovacs, John van Swieten, Masaki Takao, … Read more

Once called cellular particles, tiny bubbles may play key role in understanding, treating diseases

Journal Reference: Inna A. Nikonorova, Juan Wang, Alexander L. Cope, Peter E. Tilton, Kaiden M. Power, Jonathon D. Walsh, Jyothi S. Akella, Amber R. Krauchunas, Premal Shah, Maureen M. Barr. Isolation, profiling, and tracking of extracellular vesicle cargo in Caenorhabditis elegans. Current Biology, 2022; DOI: 10.1016/j.cub.2022.03.005 The study, which appears in the journal Current Biology, … Read more

Nanoparticle-based COVID-19 vaccine could target future infectious diseases

Journal Reference: Michelle H. Teplensky, Max E. Distler, Caroline D. Kusmierz, Michael Evangelopoulos, Haley Gula, Derek Elli, Anastasia Tomatsidou, Vlad Nicolaescu, Ian Gelarden, Anjana Yeldandi, Daniel Batlle, Dominique Missiakas, Chad A. Mirkin. Spherical nucleic acids as an infectious disease vaccine platform. Proceedings of the National Academy of Sciences, 2022; 119 (14) DOI: 10.1073/pnas.2119093119 In a … Read more

Single test for over 50 genetic diseases will cut diagnosis from decades to days

Journal Reference: Igor Stevanovski, Sanjog R. Chintalaphani, Hasindu Gamaarachchi, James M. Ferguson, Sandy S. Pineda, Carolin K. Scriba, Michel Tchan, Victor Fung, Karl Ng, Andrea Cortese, Henry Houlden, Carol Dobson-Stone, Lauren Fitzpatrick, Glenda Halliday, Gianina Ravenscroft, Mark R. Davis, Nigel G. Laing, Avi Fellner, Marina Kennerson, Kishore R. Kumar, Ira W. Deveson. Comprehensive genetic diagnosis … Read more

Possible common thread between many neurodegenerative diseases

Journal Reference: Andrew Chang, Xinyu Xiang, Jing Wang, Carolyn Lee, Tamta Arakhamia, Marija Simjanoska, Chi Wang, Yari Carlomagno, Guoan Zhang, Shikhar Dhingra, Manon Thierry, Jolien Perneel, Bavo Heeman, Lauren M. Forgrave, Michael DeTure, Mari L. DeMarco, Casey N. Cook, Rosa Rademakers, Dennis W. Dickson, Leonard Petrucelli, Michael H.B. Stowell, Ian R.A. Mackenzie, Anthony W.P. Fitzpatrick. … Read more

African ‘hotspot’ for highly infectious diseases

Journal Reference: Kefyalew Addis Alene, Ahmed Elagali, Dylan D Barth, Susan F Rumisha, Punam Amratia, Daniel J Weiss, Kendalem Asmare Atalell, Andargachew Kumsa Erena, Peter W Gething, Archie C A Clements. Spatial codistribution of HIV, tuberculosis and malaria in Ethiopia. BMJ Global Health, 2022; 7 (2): e007599 DOI: 10.1136/bmjgh-2021-007599 The new research, published today in … Read more

New artificial intelligence tool detects often overlooked heart diseases

Journal Reference: Grant Duffy, Paul P. Cheng, Neal Yuan, Bryan He, Alan C. Kwan, Matthew J. Shun-Shin, Kevin M. Alexander, Joseph Ebinger, Matthew P. Lungren, Florian Rader, David H. Liang, Ingela Schnittger, Euan A. Ashley, James Y. Zou, Jignesh Patel, Ronald Witteles, Susan Cheng, David Ouyang. High-Throughput Precision Phenotyping of Left Ventricular Hypertrophy With Cardiovascular … Read more

Simplifying RNA editing for treating genetic diseases

Journal Reference: Dhruva Katrekar, James Yen, Yichen Xiang, Anushka Saha, Dario Meluzzi, Yiannis Savva, Prashant Mali. Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs. Nature Biotechnology, 2022; DOI: 10.1038/s41587-021-01171-4 The new RNA editing technology holds promise as a gene therapy for treating genetic diseases. In a … Read more

Researchers identify potential new means of slowing neurodegenerative diseases

Journal Reference: Megan Jandy, Asra Noor, Pascal Nelson, Cassandra N. Dennys, Isabella M. Karabinas, Jeanine C. Pestoni, Gautam D. Singh, Lam Luc, Rachel Devyldere, Nathalie Perdomo, Catherine E. Mitchell, Levi Adams, Marisa A. Fuse, Francine A. Mendoza, Carrie L. Marean-Reardon, Ryan A. Mehl, Alvaro G. Estevez, Maria Clara Franco. Peroxynitrite nitration of Tyr 56 in … Read more

Debatepost