How one inflammatory disorder exacerbates another

Journal Reference: Xiaofei Li, Hui Wang, Xiang Yu, Gundappa Saha, Lydia Kalafati, Charalampos Ioannidis, Ioannis Mitroulis, Mihai G. Netea, Triantafyllos Chavakis, George Hajishengallis. Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. Cell, 2022; DOI: 10.1016/j.cell.2022.03.043 In a new paper in Cell, researchers from the School of Dental Medicine, together with an international team including … Read more

Some autism spectrum disorder symptoms linked to astrocytes

Journal Reference: Megan Allen, Ben S. Huang, Michael J. Notaras, Aiman Lodhi, Estibaliz Barrio-Alonso, Pablo J. Lituma, Paul Wolujewicz, Jonathan Witztum, Francesco Longo, Maoshan Chen, David W. Greening, Eric Klann, M. Elizabeth Ross, Conor Liston, Dilek Colak. Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling. Molecular Psychiatry, 2022; … Read more

Risky driving behaviors increase as common sleep disorder worsens

Journal Reference: Jason M Doherty, Catherine M Roe, Samantha A Murphy, Ann M Johnson, Ella Fleischer, Cristina D Toedebusch, Tiara Redrick, David Freund, John C Morris, Suzanne E Schindler, Anne M Fagan, David M Holtzman, Brendan P Lucey, Ganesh M Babulal. Adverse driving behaviors are associated with sleep apnea severity and age in cognitively normal … Read more

Disasters could disrupt care for opioid use disorder in most vulnerable communities

Journal Reference: Paul J. Joudrey, Marynia Kolak, Qinyun Lin, Susan Paykin, Vidal Anguiano, Emily A. Wang. Assessment of Community-Level Vulnerability and Access to Medications for Opioid Use Disorder. JAMA Network Open, 2022; 5 (4): e227028 DOI: 10.1001/jamanetworkopen.2022.7028 The research team, led by Paul Joudrey, MD, MPH, assistant professor of medicine (general medicine); and Yale Drug … Read more

Unexpected protein could play role in common brain disorder

Journal Reference: Yi Xiao Jiang, Qin Cao, Michael R. Sawaya, Romany Abskharon, Peng Ge, Michael DeTure, Dennis W. Dickson, Janine Y. Fu, Rachel R. Ogorzalek Loo, Joseph A. Loo, David S. Eisenberg. Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43. Nature, 2022; DOI: 10.1038/s41586-022-04670-9 Now, UCLA biochemists have discovered such fibrils in … Read more

About 1 in 4 adults has an often-missed liver disorder linked to higher heart disease risk

Journal Reference: P. Barton Duell, Francine K. Welty, Michael Miller, Alan Chait, Gmerice Hammond, Zahid Ahmad, David E. Cohen, Jay D. Horton, Gregg S. Pressman, Peter P. Toth. Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association. Arteriosclerosis, Thrombosis, and Vascular Biology, 2022; DOI: 10.1161/ATV.0000000000000153 An American Heart Association … Read more

Machine learning predicts conduct disorder in kids

Journal Reference: Lena Chan, Cortney Simmons, Scott Tillem, May Conley, Inti A. Brazil, Arielle Baskin-Sommers. Classifying Conduct Disorder using a biopsychosocial model and machine learning method. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2022; DOI: 10.1016/j.bpsc.2022.02.004 The study appears in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, published by Elsevier. The researchers used baseline data from over … Read more

Researchers discover new neurodevelopmental disorder

Journal Reference: Sarah E.M. Stephenson, Gregory Costain, Laura E.R. Blok, Michael A. Silk, Thanh Binh Nguyen, Xiaomin Dong, Dana E. Alhuzaimi, James J. Dowling, Susan Walker, Kimberly Amburgey, Robin Z. Hayeems, Lance H. Rodan, Marc A. Schwartz, Jonathan Picker, Sally A. Lynch, Aditi Gupta, Kristen J. Rasmussen, Lisa A. Schimmenti, Eric W. Klee, Zhiyv Niu, … Read more

Drug use severity in adolescence affects substance use disorder risk in adulthood

Journal References: Sean Esteban McCabe, John E. Schulenberg, Ty S. Schepis, Vita V. McCabe, Philip T. Veliz. Longitudinal Analysis of Substance Use Disorder Symptom Severity at Age 18 Years and Substance Use Disorder in Adulthood. JAMA Network Open, 2022; 5 (4): e225324 DOI: 10.1001/jamanetworkopen.2022.5324 Nora D. Volkow, Eric M. Wargo. Association of Severity of Adolescent … Read more

Evidence of brain changes in those at risk of bipolar disorder captured with MRI scans

Journal Reference: Gloria Roberts, Alistair Perry, Kate Ridgway, Vivian Leung, Megan Campbell, Rhoshel Lenroot, Philip B. Mitchell, Michael Breakspear. Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder. American Journal of Psychiatry, 2022; DOI: 10.1176/appi.ajp.21010047 Up until now, medical researchers knew that bipolar disorder was associated with reduced communication … Read more