The impact of COVID-19 on drug use — and how it contributes to overdose risk

Journal Reference: Suzan M. Walters, Rebecca S. Bolinski, Ellen Almirol, Stacy Grundy, Scott Fletcher, John Schneider, Samuel R. Friedman, Lawrence J. Ouellet, Danielle C. Ompad, Wiley Jenkins, Mai T. Pho. Structural and community changes during COVID-19 and their effects on overdose precursors among rural people who use drugs: a mixed-methods analysis. Addiction Science & Clinical … Read more

Promising drug candidates for Crimean-Congo haemorrhagic fever identified

Journal Reference: Nazif Elaldi, Ujjwal Neogi, Sofia Appelberg, Anoop Ambikan, Emma Kennedy, Stuart Dowall, Binnur K Bagci, Soham Gupta, Jimmy E Rodriguez, Sara Svensson-Akusjärvi, Vanessa Monteil, Akos Vegvari, Rui Benfeitas, Akhil Banerjea, Friedemann Weber, Roger Hewson, Ali Mirazimi. Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target. eLife, … Read more

Drug reduced frequency of breathing pauses in sleep apnea

Journal Reference: Jan Hedner, Kaj Stenlöf, Ding Zou, Erik Hoff, Corinna Hansen, Katrin Kuhn, Peter Lennartz, Ludger Grote. A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea. American Journal of Respiratory and Critical Care Medicine, 2022; DOI: 10.1164/rccm.202109-2043oc The treatment that has been tested is carbonic anhydrase (CA) inhibition, CA being … Read more

A drug that treats alcoholism may be the next anti-anxiety medication

Journal Reference: Akiyoshi Saitoh, Yoshifumi Nagayama, Daisuke Yamada, Kosho Makino, Toshinori Yoshioka, Nanami Yamanaka, Momoka Nakatani, Yoshino Takahashi, Mayuna Yamazaki, Chihiro Shigemoto, Misaki Ohashi, Kotaro Okano, Tomoki Omata, Etsuko Toda, Yoshitake Sano, Hideyo Takahashi, Kouji Matsushima, Yuya Terashima. Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice. Frontiers in Pharmacology, 2022; 13 … Read more

Adolescent drug overdose deaths rose exponentially for the first time in history during the COVID pandemic

Journal Reference: Joseph Friedman, Morgan Godvin, Chelsea L. Shover, Joseph P. Gone, Helena Hansen, David L. Schriger. Trends in Drug Overdose Deaths Among US Adolescents, January 2010 to June 2021. JAMA, 2022; 327 (14): 1398 DOI: 10.1001/jama.2022.2847 This is the first time in recorded history that the teen drug death rate has seen an exponential … Read more

Antibiotic and antiretroviral drug effects on breast milk are explored for mothers living with HIV

Journal Reference: Rabia Maqsood, Peter T. Skidmore, LaRinda A. Holland, Joshua L. Au, Adam K. Khan, Lily I. Wu, Ningxin Ma, Emily R. Begnel, Bhavna H. Chohan, Judith Adhiambo, Grace John-Stewart, James Kiarie, John Kinuthia, Michael H. Chung, Barbra A. Richardson, Jennifer Slyker, Dara A. Lehman, Efrem S. Lim. Dynamic Changes in Breast Milk Microbiome … Read more

Kisspeptin: A new drug to treat liver illness?

Journal Reference: Stephania Guzman, Magdalena Dragan, Hyokjoon Kwon, Vanessa de Oliveira, Shivani Rao, Vrushank Bhatt, Katarzyna M. Kalemba, Ankit Shah, Vinod K. Rustgi, He Wang, Paul R. Bech, Ali Abbara, Chioma Izzi-Engbeaya, Pinelopi Manousou, Jessie Yanxiang Guo, Grace L. Guo, Sally Radovick, Waljit S. Dhillo, Fredric E. Wondisford, Andy V. Babwah, Moshmi Bhattacharya. Targeting hepatic … Read more

Abundant ‘secret doors’ on human proteins could reshape drug discovery

Journal Reference: Andre J. Faure, Júlia Domingo, Jörn M. Schmiedel, Cristina Hidalgo-Carcedo, Guillaume Diss, Ben Lehner. Mapping the energetic and allosteric landscapes of protein binding domains. Nature, 2022; 604 (7904): 175 DOI: 10.1038/s41586-022-04586-4 A ground-breaking new technique developed by researchers at the Centre for Genomic Regulation (CRG) in Barcelona has revealed the existence of a … Read more

HIV drug stabilizes disease progression in metastatic colorectal cancer

Journal Reference: Mihir Rajurkar, Aparna R. Parikh, Alexander Solovyov, Eunae You, Anupriya S. Kulkarni, Chong Chu, Katherine H. Xu, Christopher Jaicks, Martin S. Taylor, Connie Wu, Katherine A. Alexander, Charly R. Good, Annamaria Szabolcs, Stefanie Gerstberger, Antuan V. Tran, Nova Xu, Richard Y. Ebright, Emily E. Van Seventer, Kevin D. Vo, Eric C. Tai, Chenyue … Read more

Structure of a bacterial ‘drug pump’ reveals new way to counter hospital-borne infection

Journal Reference: Douglas N. Brawley, David B. Sauer, Jianping Li, Xuhui Zheng, Akiko Koide, Ganesh S. Jedhe, Tiffany Suwatthee, Jinmei Song, Zheng Liu, Paramjit S. Arora, Shohei Koide, Victor J. Torres, Da-Neng Wang, Nathaniel J. Traaseth. Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus. Nature Chemical Biology, 2022; DOI: 10.1038/s41589-022-00994-9 … Read more