Plastic-eating enzyme could eliminate billions of tons of landfill waste

Journal Reference: Hongyuan Lu, Daniel J. Diaz, Natalie J. Czarnecki, Congzhi Zhu, Wantae Kim, Raghav Shroff, Daniel J. Acosta, Bradley R. Alexander, Hannah O. Cole, Yan Zhang, Nathaniel A. Lynd, Andrew D. Ellington, Hal S. Alper. Machine learning-aided engineering of hydrolases for PET depolymerization. Nature, 2022; 604 (7907): 662 DOI: 10.1038/s41586-022-04599-z This discovery, published today … Read more

New insights into fermentation enzyme will lower the chemical industry’s carbon footprint

Journal Reference: Kunio Nakata, Naoyuki Miyazaki, Hiroki Yamaguchi, Mika Hirose, Tatsuki Kashiwagi, Nidamarthi H.V. Kutumbarao, Osamu Miyashita, Florence Tama, Hiroshi Miyano, Toshimi Mizukoshi, Kenji Iwasaki. High-resolution structure of phosphoketolase from Bifidobacterium longum determined by cryo-EM single-particle analysis. Journal of Structural Biology, 2022; 214 (2): 107842 DOI: 10.1016/j.jsb.2022.107842 A technique known as cryogenic electron microscopy (cryo-EM) … Read more

New enzyme discovery is another leap towards beating plastic waste

Journal Reference: William M. Kincannon, Michael Zahn, Rita Clare, Jessica Lusty Beech, Ari Romberg, James Larson, Brian Bothner, Gregg T. Beckham, John E. McGeehan, Jennifer L. DuBois. Biochemical and structural characterization of an aromatic ring–hydroxylating dioxygenase for terephthalic acid catabolism. Proceedings of the National Academy of Sciences, 2022; 119 (13) DOI: 10.1073/pnas.2121426119 They have characterised … Read more

Bacterial enzyme makes new type of biodegradable polymer

Journal Reference: Spencer S. Macdonald, Jose H. Pereira, Feng Liu, Gregor Tegl, Andy DeGiovanni, Jacob F. Wardman, Samuel Deutsch, Yasuo Yoshikuni, Paul D. Adams, Stephen G. Withers. A Synthetic Gene Library Yields a Previously Unknown Glycoside Phosphorylase That Degrades and Assembles Poly-β-1,3-GlcNAc, Completing the Suite of β-Linked GlcNAc Polysaccharides. ACS Central Science, 2022; DOI: 10.1021/acscentsci.1c01570 … Read more

Researchers identify a novel PARP-like enzyme in mitochondria

Journal Reference: Maria Dafne Cardamone, Yuan Gao, Julian Kwan, Vanessa Hayashi, Megan Sheeran, Junxiang Xu, Justin English, Joseph Orofino, Andrew Emili, Valentina Perissi. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. Journal of Cell Biology, 2022; 221 (3) DOI: 10.1083/jcb.202101021 To characterize the enzymatic activity of NEURL4, the team led by first and co-corresponding … Read more