Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method

Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method – NovLink Home Mash S Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method We want to say thanks to the writer of this write-up for this awesome content Establishment of a pancreatic cancer animal model … Read more

Human gene variant produces attention deficit disorder-like problems in mice

Journal Reference: Eryn Donovan, Cassandra Avila, Sarah Klausner, Vinay Parikh, Cristina Fenollar-Ferrer, Randy D. Blakely, Martin Sarter. Disrupted choline clearance and sustained acetylcholine release in vivo by a common choline transporter coding variant associated with poor attentional control in humans. The Journal of Neuroscience, 2022; JN-RM-1334-21 DOI: 10.1523/JNEUROSCI.1334-21.2022 The study, led by researchers from the … Read more

Gene linked to hearing in humans also linked to touch in sea anemones

Journal Reference: Ethan Ozment, Arianna N Tamvacakis, Jianhong Zhou, Pablo Yamild Rosiles-Loeza, Esteban Elías Escobar-Hernandez, Selene L Fernandez-Valverde, Nagayasu Nakanishi. Cnidarian hair cell development illuminates an ancient role for the class IV POU transcription factor in defining mechanoreceptor identity. eLife, 2021; 10 DOI: 10.7554/eLife.74336 Cnidarians, which include jellyfish, corals and sea anemones, are the closest … Read more

A single gene controls species diversity in an ecosystem

Journal Reference: Matthew A. Barbour, Daniel J. Kliebenstein, Jordi Bascompte. A keystone gene underlies the persistence of an experimental food web. Science, 2022; 376 (6588): 70 DOI: 10.1126/science.abf2232 Plant defense genes tested with a simplified ecosystem in the lab A team of ecologists and geneticists at the University of Zurich (UZH) and the University of … Read more

How gene expression changes in the brain in Alzheimer’s disease

Journal Reference: Elena Galea, Laura D. Weinstock, Raquel Larramona-Arcas, Alyssa F. Pybus, Lydia Giménez-Llort, Carole Escartin, Levi B. Wood. Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer’s disease. Neurobiology of Disease, 2022; 166: 105655 DOI: 10.1016/j.nbd.2022.105655 Although Alzheimer’s disease is one of the most studied pathologies due to its high prevalence, … Read more

How can the computer chip predict the future of gene synthesis?

Journal Reference: Joseph Riolo, Andrew J. Steckl. Comparative analysis of genome code complexity and manufacturability with engineering benchmarks. Scientific Reports, 2022; 12 (1) DOI: 10.1038/s41598-022-06723-5 Computer programming and gene synthesis appear to share little in common. But according to University of Cincinnati professor Andrew Steckl, an Ohio Eminent Scholar, leaps forward in technology in the … Read more

Gene allowing humans to feel touch may play a role in sense of smell

Journal Reference: Xiaoyu Liang, Canyon Calovich-Benne, Adam Norris. Sensory neuron transcriptomes reveal complex neuron-specific function and regulation of mec-2/Stomatin splicing. Nucleic Acids Research, 2021; DOI: 10.1093/nar/gkab1134 Researchers from SMU (Southern Methodist University) have determined that a gene linked to feeling touch may moonlight as an olfactory gene. That’s the conclusion drawn from studying a very … Read more

Behind a good mutation: How a gene variant protects against Alzheimer’s

Journal Reference: Christel Claes, Whitney E. England, Emma P. Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P. Tsai, Morgan A. Coburn, Jessica Sanchez, Tau En Lim, Jorge L. S. Hidalgo, Christina Tu, Michael D. Cahalan, Bruce T. Lamb, Gary E. Landreth, Robert C. Spitale, Mathew Blurton‐Jones, Hayk Davtyan. The P522R … Read more

New research shows gene exchange between viruses and hosts drives evolution

Journal Reference: Nicholas A. T. Irwin, Alexandros A. Pittis, Thomas A. Richards, Patrick J. Keeling. Systematic evaluation of horizontal gene transfer between eukaryotes and viruses. Nature Microbiology, 2021; DOI: 10.1038/s41564-021-01026-3 HGT is the movement of genetic material between disparate groups of organisms, rather than by the “vertical” transmission of DNA from parent to offspring. Previous … Read more

Gene therapy strategy found effective in mouse model of hereditary disease TSC

Journal Reference: Pike-See Cheah, Shilpa Prabhakar, David Yellen, Roberta L. Beauchamp, Xuan Zhang, Shingo Kasamatsu, Roderick T. Bronson, Elizabeth A. Thiele, David J. Kwiatkowski, Anat Stemmer-Rachamimov, Bence György, King-Hwa Ling, Masao Kaneki, Bakhos A. Tannous, Vijaya Ramesh, Casey A. Maguire, Xandra O. Breakefield. Gene therapy for tuberous sclerosis complex type 2 in a mouse model … Read more