Genetic diversity of C. difficile, a particularly problematic pathogen

Journal Reference: Charles J. Norsigian, Heather A. Danhof, Colleen K. Brand, Firas S. Midani, Jared T. Broddrick, Tor C. Savidge, Robert A. Britton, Bernhard O. Palsson, Jennifer K. Spinler, Jonathan M. Monk. Systems biology approach to functionally assess the Clostridioides difficile pangenome reveals genetic diversity with discriminatory power. Proceedings of the National Academy of Sciences, … Read more

Poor diet associated with increased diabetes risk across all gradients of genetic risk

Journal Reference: Jordi Merino, Marta Guasch-Ferré, Jun Li, Wonil Chung, Yang Hu, Baoshan Ma, Yanping Li, Jae H. Kang, Peter Kraft, Liming Liang, Qi Sun, Paul W. Franks, JoAnn E. Manson, Walter C. Willet, Jose C. Florez, Frank B. Hu. Polygenic scores, diet quality, and type 2 diabetes risk: An observational study among 35,759 adults … Read more

Genetic changes differed, increased in people with Alzheimer’s disease

Journal Reference: Miller, M.B., Huang, A.Y., Kim, J. et al. Somatic genomic changes in single Alzheimer’s disease neurons. Nature, 2022 DOI: 10.1038/s41586-022-04640-1 “As we age, neurons are known to accumulate somatic mutations. In AD neurons, however, we see more mutations and DNA alterations,” said lead author Michael B. Miller, MD, PhD, of the Department of … Read more

Newly developed genetic risk scores could help sufferers, physicians make health decisions

Journal Reference: Limin Hao, Peter Kraft, Gabriel F. Berriz, Elizabeth D. Hynes, Christopher Koch, Prathik Korategere V Kumar, Shruti S. Parpattedar, Marcie Steeves, Wanfeng Yu, Ashley A. Antwi, Charles A. Brunette, Morgan Danowski, Manish K. Gala, Robert C. Green, Natalie E. Jones, Anna C. F. Lewis, Steven A. Lubitz, Pradeep Natarajan, Jason L. Vassy, Matthew … Read more

Clearest genetic signals yet for schizophrenia risk

Journal References: Tarjinder Singh, Timothy Poterba, David Curtis, Huda Akil, Mariam Al Eissa, Jack D. Barchas, Nicholas Bass, Tim B. Bigdeli, Gerome Breen, Evelyn J. Bromet, Peter F. Buckley, William E. Bunney, Jonas Bybjerg-Grauholm, William F. Byerley, Sinéad B. Chapman, Wei J. Chen, Claire Churchhouse, Nicholas Craddock, Caroline M. Cusick, Lynn DeLisi, Sheila Dodge, Michael … Read more

Genetic ‘hotspots’ that speed up and slow down brain aging could provide new targets for Alzheimer’s drugs

Genetic ‘hotspots’ that speed up and slow down brain aging could provide new targets for Alzheimer’s drugs – NovLink Home Mash E Genetic ‘hotspots’ that speed up and slow down brain aging could provide new targets for Alzheimer’s drugs We want to say thanks to the writer of this short article for this incredible material … Read more

Scientists create novel genetic model of Down syndrome in rats

Journal Reference: Yasuhiro Kazuki, Feng J. Gao, Miho Yamakawa, Masumi Hirabayashi, Kanako Kazuki, Naoyo Kajitani, Sachiko Miyagawa-Tomita, Satoshi Abe, Makoto Sanbo, Hiromasa Hara, Hiroshi Kuniishi, Satoshi Ichisaka, Yoshio Hata, Moeka Koshima, Haruka Takayama, Shoko Takehara, Yuji Nakayama, Masaharu Hiratsuka, Yuichi Iida, Satoko Matsukura, Naohiro Noda, Yicong Li, Anna J. Moyer, Bei Cheng, Nandini Singh, Joan … Read more

Single test for over 50 genetic diseases will cut diagnosis from decades to days

Journal Reference: Igor Stevanovski, Sanjog R. Chintalaphani, Hasindu Gamaarachchi, James M. Ferguson, Sandy S. Pineda, Carolin K. Scriba, Michel Tchan, Victor Fung, Karl Ng, Andrea Cortese, Henry Houlden, Carol Dobson-Stone, Lauren Fitzpatrick, Glenda Halliday, Gianina Ravenscroft, Mark R. Davis, Nigel G. Laing, Avi Fellner, Marina Kennerson, Kishore R. Kumar, Ira W. Deveson. Comprehensive genetic diagnosis … Read more

The impacts from using genetic testing to track down relatives

Journal Reference: Christi J. Guerrini, Jill O. Robinson, Cinnamon C. Bloss, Whitney Bash Brooks, Stephanie M. Fullerton, Brianne Kirkpatrick, Sandra Soo-Jin Lee, Mary Majumder, Stacey Pereira, Olivia Schuman, Amy L. McGuire. Family secrets: Experiences and outcomes of participating in direct-to-consumer genetic relative-finder services. The American Journal of Human Genetics, 2022; DOI: 10.1016/j.ajhg.2022.01.013 Among the most … Read more

Nanocarrier spray: Better crops without genetic modification

Journal Reference: Chonprakun Thagun, Yoko Horii, Maai Mori, Seiya Fujita, Misato Ohtani, Kousuke Tsuchiya, Yutaka Kodama, Masaki Odahara, Keiji Numata. Non-transgenic Gene Modulation via Spray Delivery of Nucleic Acid/Peptide Complexes into Plant Nuclei and Chloroplasts. ACS Nano, 2022; DOI: 10.1021/acsnano.1c07723 Technology allows us to directly alter genomes and create genetically modified organisms (GMOs), including GM … Read more

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