Unexpected protein could play role in common brain disorder

Journal Reference: Yi Xiao Jiang, Qin Cao, Michael R. Sawaya, Romany Abskharon, Peng Ge, Michael DeTure, Dennis W. Dickson, Janine Y. Fu, Rachel R. Ogorzalek Loo, Joseph A. Loo, David S. Eisenberg. Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43. Nature, 2022; DOI: 10.1038/s41586-022-04670-9 Now, UCLA biochemists have discovered such fibrils in … Read more

Resourceful viral protein combats monkey and human defenses differently

Journal Reference: Weitong Yao, Klaus Strebel, Shoji Yamaoka, Takeshi Yoshida. Simian Immunodeficiency Virus SIVgsn-99CM71 Vpu Employs Different Amino Acids To Antagonize Human and Greater Spot-Nosed Monkey BST-2. Journal of Virology, 2022; 96 (4) DOI: 10.1128/JVI.01527-21 In a study published in December in Journal of Virology, researchers from Tokyo Medical and Dental University (TMDU) have revealed … Read more

Design of protein binders from target structure alone

Journal Reference: Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D. DeBouver, Allison Pires, Asim K. Bera, … Read more

New advances in the protein folding process thermodynamics

Journal Reference: Marc Rico-Pasto, Annamaria Zaltron, Sebastian J. Davis, Silvia Frutos, Felix Ritort. Molten globule–like transition state of protein barnase measured with calorimetric force spectroscopy. Proceedings of the National Academy of Sciences, 2022; 119 (11) DOI: 10.1073/pnas.2112382119 The study was led by Professor Fèlix Ritort, from the Faculty of Physics and the Institute of Nanosciences … Read more

Senolytic drugs boost key protective protein

Journal Reference: Yi Zhu, Larissa G.P. Langhi Prata, Erin O. Wissler Gerdes, Jair Machado Espindola Netto, Tamar Pirtskhalava, Nino Giorgadze, Utkarsh Tripathi, Christina L. Inman, Kurt O. Johnson, Ailing Xue, Allyson K. Palmer, Tingjun Chen, Kalli Schaefer, Jamie N. Justice, Anoop M. Nambiar, Nicolas Musi, Stephen B. Kritchevsky, Jun Chen, Sundeep Khosla, Diana Jurk, Marissa … Read more

Eating protein from a greater variety of sources may lower risk of high blood pressure

Journal Reference: Chun Zhou, Qimeng Wu, Ziliang Ye, Mengyi Liu, Zhuxian Zhang, Yuanyuan Zhang, Huan Li, Panpan He, Qinqin Li, Chengzhang Liu, Xianhui Qin. Inverse Association Between Variety of Proteins With Appropriate Quantity From Different Food Sources and New-Onset Hypertension. Hypertension, 2022; DOI: 10.1161/HYPERTENSIONAHA.121.18222 Nearly half of the U.S. population has hypertension, or high blood … Read more

How a touch-sensing protein could stop constipation

Journal Reference: Lauren A. Jones, Byungchang Jin, Alyce M. Martin, Lai Wei, Seungil Ro, Damien J. Keating, Dayan de Fontgalland, Paul Hollington, David A. Wattchow, Philippa Rabbitt, Luigi Sposato, Nick J. Spencer. Diminished Piezo2-Dependent Tactile Sensitivity Occurs in Aging Human Gut and Slows Gastrointestinal Transit in Mice. Gastroenterology, 2022; DOI: 10.1053/j.gastro.2022.01.043 Now, new Flinders University … Read more

New study confirms bioengineered RSV protein vaccine evokes protective immune response

Journal Reference: Ana M. Nuñez Castrejon, Sara M. O’Rourke, Lawrence M. Kauvar, Rebecca M. DuBois. Structure-Based Design and Antigenic Validation of Respiratory Syncytial Virus G Immunogens. Journal of Virology, 2022; DOI: 10.1128/jvi.02201-21 For fifth-year Baskin Engineering student and the paper’s lead author Nuñez Castrejon, a bout of pneumonia that lingered for months when she was … Read more

Plotting the placental protein NRK: Understanding the molecular evolution processes underlying placenta acquisition in eutherian ancestors

Plotting the placental protein NRK: Understanding the molecular evolution processes underlying placenta acquisition in eutherian ancestors – NovLink Home Mash N Plotting the placental protein NRK: Understanding the molecular evolution processes underlying placenta acquisition in eutherian ancestors We would love to say thanks to the writer of this article for this remarkable web content Plotting … Read more

Mutations in SARS-CoV-2 spike protein receptor-binding domains may result in escape variants resistant to therapeutics and vaccines

Mutations in SARS-CoV-2 spike protein receptor-binding domains may result in escape variants resistant to therapeutics and vaccines – NovLink Home Mash C Mutations in SARS-CoV-2 spike protein receptor-binding domains may result in escape variants resistant to therapeutics and vaccines We want to say thanks to the writer of this write-up for this amazing content Mutations … Read more

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