Skin bacteria may boost immune response of mice vaccinated with smallpox vaccine, study shows

Journal Reference: Evgeniya V. Shmeleva, Mercedes Gomez de Agüero, Josef Wagner, Anton J. Enright, Andrew J. Macpherson, Brian J. Ferguson, Geoffrey L. Smith. Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response. PLOS Pathogens, 2022; 18 (4): e1009854 DOI: 10.1371/journal.ppat.1009854 The smallpox vaccination was administered via … Read more

Body’s response to different strains of tuberculosis could affect transmission

Journal Reference: Arianne Lovey, Sheetal Verma, Vaishnavi Kaipilyawar, Rodrigo Ribeiro-Rodrigues, Seema Husain, Moises Palaci, Reynaldo Dietze, Shuyi Ma, Robert D. Morrison, David. R. Sherman, Jerrold J. Ellner, Padmini Salgame. Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-28506-2 The findings, published in … Read more

Socioeconomic factors affect response to depression treatment

Journal Reference: Jeffrey A. Mills, Vikram Suresh, Lenisa Chang, Taryn Mayes, Paul E. Croarkin, Madhukar H. Trivedi, Jeffrey R. Strawn. Socioeconomic Predictors of Treatment Outcomes Among Adults With Major Depressive Disorder. Psychiatric Services, 2022; DOI: 10.1176/ Led by Jeffrey Mills, PhD, and Jeffrey Strawn, MD, the UC cross-college collaborative research was recently published in the … Read more

Targeted demand response reduces price volatility of electric grid

Journal Reference: Kiyeob Lee, Xinbo Geng, S. Sivaranjani, Bainan Xia, Hao Ming, Srinivas Shakkottai, Le Xie. Targeted demand response for mitigating price volatility and enhancing grid reliability in synthetic Texas electricity markets. iScience, 2022; 25 (2): 103723 DOI: 10.1016/j.isci.2021.103723 To reduce the energy load across the entirety of the state’s grid, traditional demand response studies … Read more

Research suggests interrupting immune response improves multiple sclerosis outcomes

Journal Reference: Kelly L. Monaghan, Drake Aesoph, Amanda G. Ammer, Wen Zheng, Shokofeh Rahimpour, Breanne Y. Farris, Camille A. Spinner, Peng Li, Jian-Xin Lin, Zu-Xi Yu, Vanja Lazarevic, Gangqing Hu, Warren J. Leonard, Edwin C. K. Wan. Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation. Proceedings of the National Academy of Sciences, 2021; 118 (52) DOI: 10.1073/pnas.2116256118 … Read more

Drug incorporated into silicone coating reduces ‘overseas body response’ to implants

Journal Reference: Barone, DG et al. Prevention of the foreign body response to implantable medical devices by inflammasome inhibition. PNAS, 2022 DOI: 10.1073/pnas.2115857119 Implantable electronic medical devices are already widely used for a number of applications, but they also offer the prospect of transforming the treatment of intractable conditions, such as the use of neural … Read more

How coronavirus triggers immune response in brain

Journal Reference: Olumayokun A. Olajide, Victoria U. Iwuanyanwu, Oyinkansola D. Adegbola, Alaa A. Al-Hindawi. SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia. Molecular Neurobiology, 2021; 59 (1): 445 DOI: 10.1007/s12035-021-02593-6 The study, published in the journal Molecular Neurobiology led by the University of Huddersfield’s Dr Mayo Olajide, describes how the spike protein used by … Read more

Weight problems: A dangerous immune response

Journal Reference: Susanne Stutte, Hellen Ishikawa-Ankerhold, Lydia Lynch, Sarah Eickhoff, Simona Nasiscionyte, Chenglong Guo, Dominic van den Heuvel, Daniel Setzensack, Marco Colonna, Daniela Maier-Begandt, Ludwig Weckbach, Thomas Brocker, Christian Schulz, Barbara Walzog, Ulrich von Andrian. High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue. The Journal of Immunology, 2022; … Read more

New study confirms bioengineered RSV protein vaccine evokes protective immune response

Journal Reference: Ana M. Nuñez Castrejon, Sara M. O’Rourke, Lawrence M. Kauvar, Rebecca M. DuBois. Structure-Based Design and Antigenic Validation of Respiratory Syncytial Virus G Immunogens. Journal of Virology, 2022; DOI: 10.1128/jvi.02201-21 For fifth-year Baskin Engineering student and the paper’s lead author Nuñez Castrejon, a bout of pneumonia that lingered for months when she was … Read more

Prenatal mindfulness program improves stress response in infants

Journal References: Noroña-Zhou, Amanda N.; Coccia, Michael; Epel, Elissa; Vieten, Cassandra; Adler, Nancy E.; Laraia, Barbara; Jones-Mason, Karen; Alkon, Abbey; Bush, Nicole R. The Effects of a Prenatal Mindfulness Intervention on Infant Autonomic and Behavioral Reactivity and Regulation. Psychosomatic Medicine, Mar. 10, 2022 DOI: 10.1097/PSY.0000000000001066 E. Epel, B. Laraia, K. Coleman-Phox, C. Leung, C. Vieten, … Read more