Key signaling pathway in immune cells could be new Alzheimer’s target

Journal Reference: Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue-Ann Mok, Jason E. Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan. Microglial NF-κB drives tau spreading and toxicity in a … Read more

Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease progression

Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease progression – NovLink Home Mash I Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease progression We would like to say thanks to the writer of this short article for this amazing web content Study identifies … Read more

Researchers identify an immunotherapy target to combat glioblastomas

Journal Reference: Nourhan Abdelfattah, Parveen Kumar, Caiyi Wang, Jia-Shiun Leu, William F. Flynn, Ruli Gao, David S. Baskin, Kumar Pichumani, Omkar B. Ijare, Stephanie L. Wood, Suzanne Z. Powell, David L. Haviland, Brittany C. Parker Kerrigan, Frederick F. Lang, Sujit S. Prabhu, Kristin M. Huntoon, Wen Jiang, Betty Y. S. Kim, Joshy George, Kyuson Yun. … Read more

Pierre-Emerick Aubameyang on target again as Barcelona sink Levante late – European roundup | Football News – News 24 | News in France and abroad

Pierre Emerick Aubameyang on target again as Barcelona sink Levante late

Barcelona striker Luuk de Jong scored with a header in injury time to give his side a 3-2 win over struggling Levante after a remarkable game from start to finish in which his side were awarded three penalties. Levante took a deserved lead against a lackluster Barca in the 52nd minute when captain Jose Luis … Read more

Study reports potential target and compounds to slow the development of Alzheimer’s disease

Journal Reference: Khanh V. Do, Erik Hjorth, Ying Wang, Bokkyoo Jun, Marie-Audrey I. Kautzmann, Makiko Ohshima, Maria Eriksdotter, Marianne Schultzberg, Nicolas G. Bazan. Cerebrospinal Fluid Profile of Lipid Mediators in Alzheimer’s Disease. Cellular and Molecular Neurobiology, 2022; DOI: 10.1007/s10571-022-01216-5 Specialized lipid mediators are bioactive compounds composed of polyunsaturated fatty acids like DHA and EPA. They … Read more

Design of protein binders from target structure alone

Journal Reference: Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D. DeBouver, Allison Pires, Asim K. Bera, … Read more

Nanoparticle-based COVID-19 vaccine could target future infectious diseases

Journal Reference: Michelle H. Teplensky, Max E. Distler, Caroline D. Kusmierz, Michael Evangelopoulos, Haley Gula, Derek Elli, Anastasia Tomatsidou, Vlad Nicolaescu, Ian Gelarden, Anjana Yeldandi, Daniel Batlle, Dominique Missiakas, Chad A. Mirkin. Spherical nucleic acids as an infectious disease vaccine platform. Proceedings of the National Academy of Sciences, 2022; 119 (14) DOI: 10.1073/pnas.2119093119 In a … Read more

Discovery of novel brain fear mechanisms offers target for anxiety-reducing drugs

Journal Reference: Elena Paci, Charlotte Lawrenson, Jasmine Pickford, Robert AR Drake, Bridget M Lumb, Richard Apps. Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour. eLife, 2022; 11 DOI: 10.7554/eLife.76278 Existing anxiety-reducing drugs are not always effective for all patients and often have unwanted side effects. Understanding the brain networks and mechanisms … Read more

Scientists pinpoint genetic target with promise for treating many forms of blindness

Journal Reference: Laura K. Finnegan, Naomi Chadderton, Paul F. Kenna, Arpad Palfi, Michael Carty, Andrew G. Bowie, Sophia Millington-Ward, G. Jane Farrar. SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration. International Journal of Molecular Sciences, 2022; 23 (3): 1606 DOI: 10.3390/ijms23031606 The scientists have … Read more

New study reveals potential target for alcohol-associated liver disease

Journal Reference: Lucía Barbier-Torres, Ben Murray, Jin Won Yang, Jiaohong Wang, Michitaka Matsuda, Aaron Robinson, Aleksandra Binek, Wei Fan, David Fernández-Ramos, Fernando Lopitz-Otsoa, Maria Luque-Urbano, Oscar Millet, Nirmala Mavila, Hui Peng, Komal Ramani, Roberta Gottlieb, Zhaoli Sun, Suthat Liangpunsakul, Ekihiro Seki, Jennifer E. Van Eyk, Jose M. Mato, Shelly C. Lu. Depletion of mitochondrial methionine … Read more